Latin American History & CultureHow does one define Latin America? Geographically, Latin America stretches from the Rio Grande River on the U.S.-Mexican border and Cuba, bordering the Caribbean Sea and the Atlantic Ocean, to Tierra del Fuego at the southern tip of South America. The area is two and one-half times the size of the United States. Brazil alone is slightly larger than the continental United States. Within this vast geographic region there is enormous human and physical variety.